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OCR: enty-two Motilin is a unique gut peptide. It is a if the amino-acid peptide secreted by Mº cells es the duodenal and jejunal mucosa. It incre huscle, contractility of gastrointestinal smooth transit. accelerating gastric emptying and colon sets the There is a high basal motilin output th ecretion background muscle tone (with peaks ir ctric coinciding with initiation of the myoe. e muscle complex) and which causes interdigest contraction. in are Macrolide antibiotics such as erythrom s the side motilin-receptor agonists, which expla os that are effects of diarrhoea and abdominal cra seen with use of such agents.